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November 19, 1982

Primary Immunization With Tetanus and Diphtheria Toxoids: Reaction Rates and Immunogenicity in Older Children and Adults

JAMA. 1982;248(19):2478-2480. doi:10.1001/jama.1982.03330190042028

The reaction rates and immunogenicity of primary immunization with tetanus (5 flocculation [Lf] units) and diphtheria (1.5 Lf units) toxoids were evaluated in older children and adults. Eight of 42 subjects had local reactions to one or more doses of vaccine. All subjects had protective titers to tetanus and 94% to diphtheria after two injections. Titers of antitoxins were greater in younger patients; in those younger than 19 years, they were inversely related to age.

(JAMA 1982;248:2478-2480)