The proposita of the first kindred described with dysfibronectinemic Ehlers-Danlos syndrome conceived and gave birth to a normal, unaffected infant. The ability of the gravida's plasma to support collagen-induced aggregation of normal platelets improved during the pregnancy, perhaps reflecting a change in level or functional status of fibronectin and contributing to the surprisingly normal hemostasis and wound healing she enjoyed. Ehlers-Danlos syndrome type X does not preclude safe childbearing.
Hammerschmidt DE, Arneson MA, Larson SL, Van Tassel RA, McKenna JL. Maternal Ehlers-Danlos Syndrome Type XSuccessful Management of Pregnancy and Parturition. JAMA. 1982;248(19):2487–2488. doi:10.1001/jama.1982.03330190051030
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