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December 3, 1982

Hemoglobins in Development and Differentiation

JAMA. 1982;248(21):2909. doi:10.1001/jama.1982.03330210081049

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In recent years, considerable interest in fetal hemoglobins has been stimulated by scientific and practical considerations. From the scientific point of view, learning about the mechanisms that regulate fetal hemoglobins may provide insights into the mechanisms that control the activity of various genes during development in general. On a practical level, understanding more about fetal hemoglobins may help in the treatment of hemoglobin disorders such as sickle cell anemia and Cooley's anemia. A large body of experimental and clinical evidence suggests that if fetal hemoglobin production could be induced in patients with these disorders, their disease would be substantially ameliorated, if not actually cured. Current research focuses on understanding the mechanisms of fetal hemoglobin regulation, with the hope that this knowledge will produce practical approaches to treatment.

This book covers, in a comprehensive manner, the current knowledge of hemoglobins in various stages of development in man and other species, and