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October 19, 1994

Hemophilia Foundation Recommends Prophylactic Use of Clotting Factors

JAMA. 1994;272(15):1153-1154. doi:10.1001/jama.1994.03520150019005

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EARLY PROPHYLACTIC use of clotting factors in patients with severe hemophilia is gaining acceptance as a way to prevent the pain, morbidity, and mortality associated with bleeding disorders.

Earlier this year, the National Hemophilia Foundation (NHF), New York, NY, adopted recommendations calling on physicians to consider treating young patients with severe hemophilia with appropriate clotting factors three times a week to prevent painful and crippling bleeding episodes.

For its 46th annual meeting in Dallas, Tex, next week, the foundation has scheduled two symposia on new treatment options—one for patients and their families and one for physicians.

The new recommendations are based on extensive clinical research, conducted primarily in Sweden, that shows that early primary prophylaxis may prevent painful and crippling joint damage as well as disabling or fatal brain hemorrhages, says Marilyn Manco-Johnson, MD, director of the Mountain States Regional Hemophilia Center and associate professor of pediatrics, University of Colorado

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