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December 10, 1982

The Use of Sucrose Polyester in Weight Reduction Therapy

JAMA. 1982;248(22):2963-2964. doi:10.1001/jama.1982.03330220013005

National Institutes of Health (NIH)-supported investigators report that sucrose polyester, a nonabsorbable synthetic fat, has considerable potential for weight reduction therapy in the treatment of obesity. Ingestion of sucrose polyester, whose physical properties resemble common dietary fats, allowed ten chronically obese patients to lose an average 0.2 kg (0.4 lb) per day. In addition, sucrose polyester, according to earlier studies by these investigators, also sharply reduces plasma cholesterol levels.

The findings concerning the weight reduction benefits of sucrose polyester were recently described by Dr Charles J. Glueck and colleagues at the University of Cincinnati General Clinical Research Center, funded by the Division of Research Resources, NIH (Am J Clin Nutr 1982; 35:1352-1359).

They reported that the use of up to 60 g of sucrose polyester per day, covertly substituted for conventional dietary fat in a double-blind study, allowed the ten obese patients to ingest a diet that tastes, looks, and