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December 10, 1982

Vibrio cholerae Infections-Reply

Author Affiliations

University of Texas Medical Branch Galveston

JAMA. 1982;248(22):2972. doi:10.1001/jama.1982.03330220018020

In Reply.—  Cholera is defined as "an acute infectious disease caused by Vibrio cholerae and characterized by severe diarrhea and extreme fluid and electrolyte depletion, and by vomiting, muscle cramps and prostration."1 We used the term cholera in our article according to this established definition, which is based on clinical rather than epidemiologic characteristics. We are aware of the differences between disease caused by 01 v non-01 V cholerae, and we addressed this point in the introductory paragraph and in the "Comment" section of our article. A major point of our paper was that non-01 V cholerae infections may be clinically indistinguishable from 01 V cholerae infections. This observation underscores the importance of accurate microbiological evaluation in patients with clinical manifestations that suggest cholera to establish a specific etiologic diagnosis that can form the basis for follow-up epidemiologic investigations.