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January 14, 1983

Absorption of Enteric-Coated Aspirin

Author Affiliations

Monroe Community Hospital Rochester, NY

JAMA. 1983;249(2):192. doi:10.1001/jama.1983.03330260016011

To the Editor.—  In Dr Bland's comments (1982;247:2660) on the article entitled "Nonsteroidal Anti-inflammatory Agents in Rheumatoid Arthritis and Ankylosing Spondylitis" by Wasner et al (1981;236:2168), he noted that "there remains doubt that enteric-coated aspirin absorbs with enough predictability to make it worthwhile to use."This criticism of enteric-coated aspirin was certainly justified (20 to 30 years ago) when the enteric coating was usually shellac. However, the recommended coating in use today is cellulose acetate phthalate, which works well. At least two major types of enteric-coated aspirin on the market, Ecotrin and Enseals, use this coating. In addition to our study1 specifically comparing enteric-coated aspirin and regular aspirin, a number of other studies2-5 have been done, all of which have shown that the levels reached with enteric-coated aspirin were in most cases equal to and, in some cases, slightly better. By statistical analysis, there were no differences from