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January 21, 1983

More studies show human insulin's benefit

JAMA. 1983;249(3):328. doi:10.1001/jama.1983.03330270010005

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"The X he advantage of human insulin? It may be less immunogenic than animal insulins. It may be the drug of choice for the subpopulation of diabetics that becomes allergic to animal insulins."

So concluded Philip Fireman, MD, of the University of Pittsburgh School of Medicine at the 11th Congress of the International Diabetes Federation in Nairobi following a symposium on the clinical potential of "human" insulin made either by recombinant DNA techniques or by a novel method: enzymatic conversion of porcine insulin.

In a prospective study of the serum IgE antibody responses to insulin of 90 newly diagnosed insulin-dependent diabetics who received either purified porcine insulin or human insulin prepared by recombinant DNA techniques, Fireman found that the antibodies were present more frequently in the sera of patients who had received animal insulins.

Specifically, he found that after a year of taking one or the other preparation, insulin-specific IgE