A 17-year-old black male with sickle cell trait collapsed after completion of a 5,000-m cross-country race. He manifested CNS dysfunction, disseminated intravascular coagulation, rhabdomyolysis, renal insufficiency, and deep venous thrombosis. Sickle cell crisis may have been etiologic in the pathogenesis of this constellation of abnormalities.
Helzlsouer KJ, Hayden FG, Rogol AD. Severe Metabolic Complications in a Cross-Country Runner With Sickle Cell Trait. JAMA. 1983;249(6):777–779. doi:10.1001/jama.1983.03330300061037
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