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February 18, 1983

Amenorrhea Associated With Carotenemia

Author Affiliations

From the Department of Obstetrics and Gynecology, Rutgers Medical School, New Brunswick, NJ.

JAMA. 1983;249(7):926-929. doi:10.1001/jama.1983.03330310056029

Data are presented for ten women with anovulation, nine of them with amenorrhea, who have associated carotenemia. Classic explanations for carotenemia in amenorrheic patients have been weight loss or anorexia nervosa, yet carotenemia in our patients appeared to be diet induced. All patients consumed a pure or predominantly vegetarian diet; there was no intake of red meats. Clinical and laboratory data of the patients are presented. The amenorrhea of the patient is consistent with hypothalamic hypogonadotropic anovulation (HHA). It appeared that diet modification not only led to reduction in carotene levels, but also improved the menstrual status. The association of carotenemia and menstrual disorders is reviewed. The possibility that carotenemia is related to the development of HHA is discussed.

(JAMA 1983;249:926-929)