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January 9, 1991

Toxoplasmosis Testing During Pregnancy-Reply

Author Affiliations

Memorial Hospital of Rhode Island Pawtucket

Memorial Hospital of Rhode Island Pawtucket

JAMA. 1991;265(2):211. doi:10.1001/jama.1991.03460020065017

In Reply. —  We appreciate Dr Frenkel's comments, which emphasize what we believe to be the most important aspect of preconception care: the ability of health professionals to provide comprehensive health promotion and counseling to reduce risks to future pregnancy. We agree that serological testing for antibody against Toxoplasma gondii during pregnancy is not optimal because of the poor predictive value of such testing; however, testing before pregnancy does have benefit over testing during pregnancy since those already positive and therefore not in need of further testing or hygienic measures in any future pregnancy are identified. The prevalence of toxoplasmosis infection and the prevalence of susceptibility to new infection during pregnancy vary greatly in the different parts of the United States, ranging from 50% to 95% susceptibility,1 and the extent of the morbidity and mortality due to toxoplasmosis is not known with certainty.2 Subtracting those who test positive