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March 11, 1983

Seminoma and Epididymal Cysts in a Young Man With Known Diethylstilbestrol Exposure In Utero

Author Affiliations

From the Departments of Urology (Drs Conley, Sant, and Mitcheson) and Pathology (Dr Ucci), Tufts-New England Medical Center, Boston.

JAMA. 1983;249(10):1325-1326. doi:10.1001/jama.1983.03330340067035

EXPOSURE of women to diethylstilbestrol in utero has been linked to the development of adenosis and clear cell adenocarcinoma of the vagina.1,2 A variety of male genital tract abnormalities, including epididymal cysts, maldescended testes, hypoplastic testes, varicoceles, and spermatozoal defects, occur with increased incidence in men exposed to diethylstilbestrol in utero.3,4 Testicular tumors occur in adult mice given diethylstilbestrol,5 and preneoplastic testicular changes have been described in mice exposed prenatally to diethylstilbestrol.6 The possibility of carcinogenesis has been suggested in diethylstilbestrol-exposed males,3,4 but, to our knowledge, until now no case of testicular cancer has been documented in a person exposed in utero to diethylstilbestrol.

We report a seminoma and ipsilateral epididymal cysts in a 28-year-old man with known diethylstilbestrol exposure.

Report of a Case  A 28-year-old man was first seen with a large, painless scrotal mass that had slowly developed during one year. Antenatally, his