To the Editor.—
Gold et al1 studied chronic fatigue syndrome and EBV. At enrollment of study subjects, all were negative for the antibody to human immunodeficiency virus. However, they fail to mention if any of the subjects converted to positive for the antibody while enrolled in the project (mean duration, 11.3 months, with a range of 3 to 21 months). Did any subjects seroconvert during the follow-up, and, if so, did this play a role in patient outcome?
Todd Janus. Chronic Fatigue Syndrome. JAMA. 1991;265(3):358. doi:10.1001/jama.1991.03460030063027