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March 18, 1983

The Multiple Risk Factor Intervention Trial

Author Affiliations

Bridgeport, Conn

JAMA. 1983;249(11):1436. doi:10.1001/jama.1983.03330350017011

To the Editor.—  The risk factorreduction data are derived mainly from the results of the Framingham study. The formula used in that investigation holds that a 10% reduction of the SC level of the US population will effect a 24.4% decrease in CHD incidence and that a 50% SC reduction will result in an incredible 84% reduction of CHD incidence, assuming a linear regression. This formula, erroneously modified from the original publication, equates risk with incidence. These figures are said to be valid for one year only, not for the six years of the MRFIT program. A more correct interpretation should read that CHD is 24.4% less likely to develop in those persons whose SC level is 10% lower than that of the average low-risk population.1Also used in arriving at the recommended SC reduction is the Walker-Duncan formula, wherein the figures represented hits, near-misses, and misses against various