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March 18, 1983

Double-blind Study of Lorazepam and Diazepam in Status Epilepticus

Author Affiliations

From the Department of Neurology and the Comprehensive Epilepsy Program, University of Minnesota, St Paul (Drs Leppik and Patrick); the Wyeth Laboratories and the Thomas Jefferson University, Philadelphia [ill] Derivan); the University of Texas Health Science Center at Dallas (Drs Homan and Walker); and the Veterans Administration Medical Center and the University of Miami School of Medicine, Miami (Dr Ramsay).

JAMA. 1983;249(11):1452-1454. doi:10.1001/jama.1983.03330350028021

Lorazepam was compared with diazepam for the treatment of status epilepticus in a double-blind, randomized trial. Seventy-eight patients with 81 episodes were enrolled. Patients received one or two doses of either 4 mg of lorazepam or 10 mg of diazepam intravenously. Seizures were controlled in 89% of the episodes treated with lorazepam and in 76% treated with diazepam. The times for onset of action of the medications did not differ significantly. Adverse effects occurred in 13% of the lorazepam-treated patients and in 12% of the diazepam-treated patients. Respiratory depression and arrest, the most frequent adverse effects, were treated symptomatically; no adverse sequelae were noted.

(JAMA 1983;249:1452-1454)