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March 18, 1983

Transplacental Transmission of Pemphigus

Author Affiliations

From the Department of Obstetrics, Gynecology, and Reproductive Sciences (Drs Wasserstrum and Laros) and the Cardiovascular Research Institute (Dr Wasserstrum), University of California, San Francisco.

JAMA. 1983;249(11):1480-1482. doi:10.1001/jama.1983.03330350056029

In a pregnancy complicated by maternal pemphigus vulgaris (PV), pemphigus IgG was found both in the fetal circulation and fixed to fetal epidermis in the characteristic intercellular distribution. Light microscopic examination of fetal skin was diagnostic of PV. These findings indicated transplacental transmission of PV. They also strongly support the pathogenic role of PV antibodies and the concept of PV as a tissue-specific autoimmune disease. The occurrence of intrauterine death despite careful antepartum surveillance underscores the management problems encountered when pemphigus coexists with pregnancy.

(JAMA 1983;249:1480-1482)