Four patients with severe chronic immune thrombocytopenic purpura who were refractory to all conventional therapy for that disorder were initially seen with either refractory bleeding or the necessity for an operation. We treated each of these patients with intravenous human serum immunoglobulin, and three of the four patients had a rapid and substantial increase in their platelet counts. This new method for ameliorating chronic immune thrombocytopenic purpura deserves further study and consideration.
Carroll RR, Noyes WD, Kitchens CS. High-Dose Intravenous Immunoglobulin Therapy in Patients With Immune Thrombocytopenic Purpura. JAMA. 1983;249(13):1748–1750. doi:10.1001/jama.1983.03330370058033
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: