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April 1, 1983

High-Dose Intravenous Immunoglobulin Therapy in Patients With Immune Thrombocytopenic Purpura

Author Affiliations

From the Division of Hematology, Department of Medicine (Drs Carroll, Noyes, and Kitchens), and Department of Pathology (Dr Kitchens), University of Florida; and Veterans Administration Medical Center (Dr Kitchens), Gainesville, Fla.

JAMA. 1983;249(13):1748-1750. doi:10.1001/jama.1983.03330370058033

Four patients with severe chronic immune thrombocytopenic purpura who were refractory to all conventional therapy for that disorder were initially seen with either refractory bleeding or the necessity for an operation. We treated each of these patients with intravenous human serum immunoglobulin, and three of the four patients had a rapid and substantial increase in their platelet counts. This new method for ameliorating chronic immune thrombocytopenic purpura deserves further study and consideration.

(JAMA 1983;249:1748-1750)