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Article
April 22, 1983

Antacid Variability

Author Affiliations

Albert Einstein College of Medicine New York

JAMA. 1983;249(16):2179. doi:10.1001/jama.1983.03330400031017

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Abstract

To the Editor.—  In the response of Daniel B. Caplan, MD (1982;248:1643), regarding the treatment of duodenal ulcers with antacids, he states that "a dose of 20 to 30 mL should be adequate."Unfortunately, the buffering capacity of different liquid antacids is variable. According to Harrison's Principles of Internal Medicine, ed 9, the relative potency of liquid antacid preparations ranges from magnesium hydroxide, 256 mEq/30 mL, to aluminum phosphate gel, 12 mEq/30 mL. To obtain a buffer of 144 mEq, this would necessitate the use of 17 mL and 360 mL, respectively.It is obvious that different liquid antacids require vastly different therapeutic dosages. I wonder how aware prescribing physicians are of this fact.

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