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The medical community owes much to Dr Freedman for his pioneering work more than a decade ago in developing an experimental animal model of endocarditis. Now Dr Freedman provides us with a clinically oriented book on endocarditis and related vascular infections (the fifth in a series of volumes devoted to current topics in infectious disease).
Spanning the spectrum from the laboratory to the bedside, the author leaves few stones unturned. He carefully lays the groundwork by showing how vegetations form on endothelial surfaces, why only certain bacterial strains colonize the vegetations, and what the consequences of such processes are. With the insight of the dedicated student of endocarditis that he is, the author probes the subject from anatomy to zygomyces. We read about the controversy concerning potential benefits of addition of aminoglycosides to penicillinase-resistant penicillins for treatment of staphylococcal endocarditis. Recommendations for endocarditis prophylaxis are offered. Permeating most discussions is
Smilack JD. Infective Endocarditis and Other Intravascular Infections. JAMA. 1983;249(17):2398. doi:10.1001/jama.1983.03330410076040
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