Our article did not suggest that appropriate use of sedation before a CT scan be discouraged, and we agree that such a conclusion should not be inferred from our data. We also agree with Drs Sander and Lo that children must be carefully observed after routine sedation.The complication rate reported by Drs Sander and Lo cannot be compared to the rate that we reported from the Pediatric Drug Surveillance Program.1 This program, which has as a major objective the detection, description, and quantification of adverse drug reactions in hospitalized children, uses trained nurses to monitor in detail the hospital courses of patients and to collect information, in a standardized format, regarding a wide range of adverse reactions. It is unclear how Drs Sander and Lo identified the reactions they report, but it must be emphasized that the method of detection will bear substantially on the findings.
Mitchell AA, Louik C, Lacouture PG, Goldman P, Shapiro S. Computed Tomographic Premedication in Children-Reply. JAMA. 1983;249(19):2639. doi:10.1001/jama.1983.03330430021018
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