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May 20, 1983

Controversial Practices in Allergy

Author Affiliations

Teaneck, NJ

JAMA. 1983;249(19):2639-2640. doi:10.1001/jama.1983.03330430021019

To the Editor.—  In the SPECIAL COMMUNICATION by Grieco entitled "Controversial Practices in Allergy" (1982; 247:3106), Grieco raised issue with the clinical usefulness of the radioallergosorbent (RAST) test in general and our modification of the RAST1 in particular. Using the data obtained from one report2 and a short abstract,3 he made two critical judgments regarding our system; that is, he repeated their concern regarding both the specificity of the modified RAST and the ability of the physician to use the score obtained as a guide in selecting a safe initial immunotherapy dose. A careful analysis of the reported data shows that such conclusions are not warranted.In regard to the first matter, Grieco refers to the observation that a non-IgE-containing material was scored "false-positive" in one third (7/21) of the modified RAST assays. This is an error. The scores were actually reported as "equivocal." He also failed