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May 27, 1983

Israeli scientist receives cancer research award

JAMA. 1983;249(20):2752. doi:10.1001/jama.1983.03330440010005

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Geneticist Leo Sachs, PhD, whose curriculum vitae lists such disparate accomplishments as the hybridization of tomatoes, the development of amniocentesis, and the reversal of malignancy in certain tumor cell lines, is the recipient of the sixth annual BristolMyers award for Distinguished Achievement in Cancer Research. Sachs, chair of the Department of Genetics, the Weizmann Institute of Science, Rehovot, Israel, received the $50,000 prize at a luncheon in New York City this spring.

Sachs was cited for his "landmark discoveries that suggest a possible new approach to cancer treatment—one based not on killing cancer cells, but on actually reversing the malignant process."

His discoveries stem from research in the mid1960s indicating that a certain protein in the supernatant fluid of cultures of myeloid precursor cells could induce the formation of granulocytes and macrophages. He subsequently determined that the protein, called "macrophage and granulocyte inducer" (MGI), is secreted by a variety of