Two patients, after several weeks of zomepirac sodium use, experienced acute toxic eruption, fever, lymphadenopathy, arthralgias, angioedema of the hands, and eosinophilia. We believe that these cases represent type 3 allergic reactions to zomepirac.
Kiani R, Kushner M. Zomepirac-Induced Serum Sickness: A Report of Two Cases. JAMA. 1983;249(20):2812–2813. doi:10.1001/jama.1983.03330440050032
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