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June 17, 1983

Greater IUD perforation risk, lactation linked

JAMA. 1983;249(23):3152. doi:10.1001/jama.1983.03330470010004

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Women who have an intrauterine device (IUD) inserted during lactation run a tenfold greater risk of uterine perforation than do nonlactating women, according to a nine-center Women's Health Study.

The study, organized to examine various complications of IUD use, was supported by the National Institute of Child Health and Human Development, Bethesda, Md.

Results of this phase of the investigation were generated from a study group of 32 women hospitalized for uterine perforation necessitating transperitoneal IUD removal and a control group of 497 women, matched by age and race, who had worn IUDs uneventfully for a mean period of 15 months (Obstet Gynecol 1983;61:31-36).

Thirty-one women (97%) in the study group had given birth, compared to 337 (68% ) in the control group. Because the correlation between parity and uterine perforation was so strong, the investigators restricted further analysis to women in both groups who had borne children. They then determined