[Skip to Content]
[Skip to Content Landing]
July 1, 1983

No obvious reason for HBV double hit

JAMA. 1983;250(1):20. doi:10.1001/jama.1983.03340010012005

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Complete clinical recovery from active hepatitis B (HBV) viral infection is no guarantee that the disease will not recur if the experience of a group of investigators at the National Institutes of Health (NIH) is any guide.

Of 25 patients seen at the NIH's Clinical Center with a history of chronic HBV infection, all of whom were deemed to have made a complete recovery, eight subsequently redeveloped active disease—apparently spontaneously. The finding adds yet another element of mystery to the still-unfolding story of HBV.

"It is a new and distinct phenomenon that may have serious implications concerning the prognosis and progression of liver disease in these patients," Gary L. Davis, MD, told the annual meeting of the American Gastroenterological Association in Washington, DC. Davis is with the Liver Diseases Section, Digestive Diseases Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Md.

Reactivation of hepatitis B has been