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August 26, 1983

Amoxapine Overdose: Seizures and Fatalities

Author Affiliations

From the National Capital Poison Center and the Department of Emergency Medicine, Georgetown University Hospital, Washington, DC (Dr Litovitz); and the New Mexico Poison, Drug Information, and Medical Crisis Center and the College of Pharmacy, University of New Mexico, Albuquerque (Dr Troutman).

JAMA. 1983;250(8):1069-1071. doi:10.1001/jama.1983.03340080047027

Thirty-three amoxapine overdoses, including five fatalities, were reported to two regional poison centers over an 18-month study period. The 15.2% mortality rate stands in alarming contrast to the 0.7% death rate for all other cyclic antidepressant overdoses reported to these same two centers during the study. Seizure activity was noted in 36.4% of amoxapine overdoses, compared with 4.3% of other cyclic antidepressant poisonings. Amoxapine appears to be responsible for a disproportionate share of seizures and deaths resulting from cyclic antidepressant overdose.

(JAMA 1983;250:1069-1071)