The apparent complexity of quantitative buffy coat analysis that Fischer and Addison refer to in their letter was certainly true in our prototype instrumentation and methodology. A system is currently being manufactured that can be easily operated by personnel who have no laboratory training. The instrument incorporates a microprocessor that uses the described algorithms instantly to display results after the measurements are made. Results are available in less than 12 minutes, with about one minute of actual hands-on time. We polled five senior hematology technologists, and they stated that the same tests, when performed by their most skilled technologists using the methods described by Fischer and Addison, would take at least 25 minutes, the majority of that being hands-on time.In our article, the data were taken in a manner that would show the worst case performance of the system. Data were gathered over a period of weeks,
Wardlaw S, Levine RA. Quantitative Buffy Coat Analysis-Reply. JAMA. 1983;250(10):1272. doi:10.1001/jama.1983.03340100016011
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