PATIENTS with β-thalassemia intermedia often have radiological bone and soft-tissue findings of extra-medullary hematopoiesis. Most often described in the thorax and cranium, these soft-tissue masses may be found at any site along the vertebral column.
Report of a Case
During a yearly pelvic examination, a 36-year-old black woman was noted to have a pelvic mass. At age 12, a diagnosis of β-thalassemia major (homozygous) intermedia was made.Examination disclosed that the liver was palpable 3 cm below the right costal margin and an enlarged spleen was detected 7 cm below the left costal margin. The uterus was of normal size and displaced anteriorly; the adnexae were normal. A 6-cm cul-de-sac mass was described as firm, immobile, nontender, and smooth. The superior border could not be delineated.The hematocrit reading was 25.5%, and the WBC count was 5,600/cu mm, with a normal differential cell count. Erythrocyte indexes were microcytic and hypochromic.
Newton KL, McNeeley SG, Novick M. Extramedullary Hematopoiesis Presenting as a Pelvic Mass in a Patient With β-Thalassemia Intermedia. JAMA. 1983;250(16):2178–2179. doi:10.1001/jama.1983.03340160064034
Customize your JAMA Network experience by selecting one or more topics from the list below.