[Skip to Content]
[Skip to Content Landing]
November 25, 1983

'Bubble boy' reacts well to marrow transplant

JAMA. 1983;250(20):2751. doi:10.1001/jama.1983.03340200009004

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Twelve years of life in a plastic isolator bubble may be part of the past for David, the world's longest survivor of untreated severe combined immunodeficiency (SCID). On Oct 21, David received a bone marrow transplant from his 15-year-old sister at Texas Children's Hospital, Houston. The treatment— if successful—will free him to live in the open environment.

It now appears that the risk period for the possible occurrence of acute graft v host disease (GVHD) has passed and, according to William T. Shearer, MD, Baylor College of Medicine, Houston, who heads the medical team caring for David, "his condition is excellent. We're very pleased with his medical progress and frame of mind. We're optimistic at this point."

The signs of acute GVHD that the physicians were watching for in the first ten or so days were fever, rash, swollen glands, liver enlargement, and elevated liver enzymes. In an effort to