The simultaneous renal clearances of iothalamate sodium I 125, cyanocobalamin Co 57, and inulin were compared in 19 patients with a variety of renal diseases. The renal clearances of both iothalamate sodium I 125 and cyanocobalamin Co 57 are not statistically different from the clearance of inulin or from each other. Plasma protein binding was insignificant with iothalamate sodium I 125 but averaged 22% with cyanocobalamin Co 57 with a considerable variation between patients. These observations, as well as a lower cost per study, suggest that iothalamate sodium I 125 is an excellent radioactive material to substitute for inulin clearance when measuring the glomerular filtration rate in man.
Anderson CF, Sawyer TK, Cutler RE. Iothalamate Sodium I 125 vs Cyanocobalamin Co 57 as a Measure of Glomerular Filtration Rate in Man. JAMA. 1968;204(8):653–656. doi:10.1001/jama.1968.03140210007002
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