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May 20, 1968

Primary Lymphedema Associated With Yellow Nails and Pleural Effusions

Author Affiliations

From the sections of dermatology (Dr. Kierland) and medicine (Drs. Randall and Shick), Mayo Clinic and Mayo Foundation; and dermatology (Dr. Dilley), Mayo Graduate School of Medicine (University of Minnesota), Rochester.

JAMA. 1968;204(8):670-673. doi:10.1001/jama.1968.03140210024005

The association of primary lymphedema with pleural effusions and yellowish discoloration of the nails has been well documented, mainly in the British literature. Five additional cases, with various combinations of primary lymphedema, yellow nails, and pleural effusions, indicate that a common etiologic relationship is likely.