[Skip to Content]
[Skip to Content Landing]
February 3, 1984

Amoxapine Overdosage-Reply

Author Affiliations

National Capital Poison Center Georgetown University Hospital Washington, DC
New Mexico Poison, Drug Information and Medical Crisis Center College of Pharmacy University of New Mexico Albuquerque

JAMA. 1984;251(5):602. doi:10.1001/jama.1984.03340290021007

In Reply.—  The Lederle authors, describing our research as "incomplete," cite two articles that they believe we have overlooked. The amoxapine overdose series of Kulig et al,1 however, was cited in our manuscript but never mentions a higher convulsion rate compared with other cyclic antidepressants despite the occurrence of seizures in 100% of the reported patients. Another letter by two of the correspondents2 had not yet been published when our manuscript was submitted but does state that "convulsive seizures after an overdose, although not uncommon with the older TCAs [tricyclic antidepressants], may be more common with amoxapine."Our study populations included all cases reported to the two poison control centers during the 18-month study period. We are unable to identify any reporting bias favoring more severe amoxapine cases as compared with other cyclic antidepressants. Our data include a slightly but not significantly higher percentage of pediatric ingestions in