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March 2, 1984

Viral infection may lead to vessel wall problems

JAMA. 1984;251(9):1131-1132. doi:10.1001/jama.1984.03340330007003

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A link was drawn between viruses, vasculitis, and possibly thrombosis in other research on the inflammatory process reported at the American Heart

Association's Florida forum Douglas B. Cines, MD, University of Pennsylvania School of Medicine, Philadelphia, says he and colleagues used human umbilical vein endothelial cell cultures to "establish that infection with herpes simplex type 1 virus programs the endothelial cell to produce large quantities of viral proteins."

As the virus replicates within the endothelium, he says, "these viral proteins become inserted into the surface of the endothelial cell, where they bind antibodies and/or complement-coated immune complexes. This enhanced binding of immune complexes could attract activated complement proteins and leukocytes from the circulation. In turn, these two systems are capable of initiating inflammation."

Furthermore, Cines says, the resulting "immunologic endothelial cell injury could initiate platelet adherence. In turn, this adherence may lead to the thromboses that occur in certain vasculitic