To the Editor.—
Hepatitis possibly caused by ranitidine has been reported but is seemingly rare.1 Hepatic toxicity is also infrequently associated with cimetidine, another H2-receptor antagonist.2 I wish to report apparent hepatitis in a patient after two weeks of treatment with ranitidine for esophageal reflux.
Report of a Case.—
A 50-year-old woman was seen with a two-year history of retrosternal burning pain, bloating, and regurgitation of food not relieved by antacid and elevation of the head of her bed. Two months prior to this visit a course of cimetidine had provided symptomatic benefit. A small hiatal hernia was now demonstrated on upper gastrointestinal tract series. Ranitidine, 150 mg, was given because the patient expressed a preference for twice-a-day dosing afforded by this drug. Fifteen days later she experienced an illness characterized by marked malaise, weakness, nausea, vomiting, headache, and steady pain in the right upper portion
Proctor JD. Hepatitis Associated With Ranitidine. JAMA. 1984;251(12):1554. doi:10.1001/jama.1984.03340360022014
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