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April 20, 1984

Serological Response to Rubella Revaccination

Author Affiliations

From the Division of Field Services, Epidemiology Program Office (Dr Serdula), and the Division of Viral Diseases, Center for Infectious Diseases (Dr Herrmann), Centers for Disease Control, Atlanta; and the School of Tropical Medicine, University of Hawaii, Honolulu (Dr Halstead).

JAMA. 1984;251(15):1974-1977. doi:10.1001/jama.1984.03340390028023

To document the serological response, 21 seronegative rubella vaccinees (hemagglutination inhibition [HI] titer <10) were revaccinated with RA 27/3 rubella vaccine. All demonstrated an anamnestic response. Although RA 27/3 vaccine was an effective booster, antibody boost was not maintained in some persons. Of 15 persons tested, 24 to 27 months after revaccination, six had a significant HI antibody drop (fourfold or greater); only one had lost all detectable HI antibody. Although all 21 study participants were initially HI seronegative by rubella HI testing, 16 (76.2%) possessed neutralization and/or enzyme-linked immunosorbent assay antibodies before revaccination. As more persons with vaccine-induced immunity join the adult population pool, more sensitive test methods may be needed to assess serological status accurately.

(JAMA 1984;251:1974-1977)