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May 4, 1984

Papillomavirus invades esophagus, incidence seems to be increasing

JAMA. 1984;251(17):2185-2187. doi:10.1001/jama.1984.03340410005003

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Infection of the esophagus by human papillomavirus (HPV)—an agent that some studies have linked to the development of intraepithelial neoplasia and invasive squamous cell carcinoma in other body areas (Cancer Res 1979;39:1074-1082, Int J Gynecol Pathol 1982; 1:75-94)—was reported for what is believed to be the first time at the recent meeting of the International Academy of Pathology in San Francisco.

And, the principal investigator told JAMA MEDICAL NEWS, incidence of the virus, which is acquired either congenitally or through sexual transmission, may be increasing because of an apparent growing prevalence of oral-genital sexual intercourse. The study continues.

The investigator, Barbara Winkler, MD, assistant professor of pathology, State University of New York at Stony Brook School of Medicine, told the group that while hyperplastic and papillomatous lesions of the esophagus have been mentioned sporadically in the literature since the early 1920s, the incidence of true squamous papillomas of the esophagus