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May 18, 1984

Fetal Hydrocephalus: II. Amelioration of Fetal Porencephaly by In Utero Therapy in Nonhuman Primates

Author Affiliations

From the Pregnancy Research Branch, National Institute of Child Health and Human Development (Drs Michejda and Hodgen); and Surgical Neurlogy Branch, Neuroradiology and Computed Tomography Section, National Institute of Neurological and Communicative Disorders and Stroke (Drs Patronas and Di Chiro), National Institutes of Health, Bethesda, Md. Dr Michejda is now at Georgetown University Hospital, Washington, DC.

JAMA. 1984;251(19):2548-2552. doi:10.1001/jama.1984.03340430046027

The postnatal course of a form of infantile porencephaly under pressure in monkeys was evaluated by comparing brain development between animals that had received the hydrocephalic antenatal vent for intrauterine treatment and those that had not been treated antenatally. Brain development was assessed by computed tomographic scans. The studies showed asymmetric malformations and associated porencephalic lesions in infant monkeys not treated in utero, despite installation of a conventional postnatal ventriculoperitoneal shunt. In contrast, apparently normal development of brain tissue in infants given intrauterine therapy was observed.

(JAMA 1984;251:2548-2552)