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May 25, 1984

Bone Metastasis: Monitoring and Treatment

Author Affiliations

Albany, NY

JAMA. 1984;251(20):2728. doi:10.1001/jama.1984.03340440084044

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This multiauthored book attempts to address the pathophysiology, screening and monitoring, management, and evaluation of response of metastatic bone disease—an ambitious undertaking, to be sure. The practical result is a not inappropriate focus on breast cancer and, to a much lesser extent, on prostate cancer, with only a cursory mention of other malignant neoplasms involving bone.

The first section deals with the pathophysiology of metastatic bone disease. In addition to providing a scientific underpinning for the more clinically oriented sections that follow, these chapters provide a concise overview of a vast body of literature.

Sections on screening for and monitoring and evaluation of response of bone metastases are mainly concerned with methods of imaging. While isotopic bone scanning is correctly identified as the single most valuable means to accomplish these goals, the authors make something of a plea for greater use of bone scans for screening and follow-up of metastatic