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June 8, 1984

Depression Associated With Candida albicans Infections

Author Affiliations

Jackson, Tenn

JAMA. 1984;251(22):2928-2929. doi:10.1001/jama.1984.03340460018011

To the Editor.—  In a recent article, Gold and Pearsall1 commented, "Patients seen for evaluation of depression may have either a primary affective disorder or one secondary to some medical illness."I am writing to report that depression is commonly related to prolonged or repeated courses of broad-spectrum antibiotics or to birth control pills, which promote the overgrowth of Candida albicans on mucous membranes.2,3Although mechanisms involved still have not been clearly elucidated, it appears that toxins produced by excessive Candida growth affect various parts of the body, including the immune and endocrine systems and neurotransmitters.Depression and other disorders related to C albicans can be suspected from clinical history, followed by a therapeutic response to oral nystatin and a yeast-free, low-carbohydrate diet.

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