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June 15, 1984

Clinical Pharmacology in Obstetrics

Author Affiliations

Bluefield, WVa

JAMA. 1984;251(23):3149. doi:10.1001/jama.1984.03340470069033

Pregnancy is a therapeutic orphan, says Dr Peter Lewis, the editor of this book. While there have been profound changes and rapid growth in the fields of pharmacology and obstetrics in the last three decades, there has been an understandable reluctance on the part of drug companies to endorse trials of their drugs in pregnant patients.

This book looks at the cutting edge of drug therapy in pregnancy today. The first three chapters, which are written by Dr Lewis himself, deal with the effect of drugs on the mother and on the fetus. The pharmacokinetics of drugs in a two-compartment (mother and fetus) system are discussed and diagramed. A careful reading of these chapters may help someone to understand why the fetus may have a higher concentration of the drug in its system than the mother.

The remaining 22 chapters of the book are handled by 27 contributing editors who