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June 22, 1984

The Isotretinoin Teratogen Syndrome

Author Affiliations

From the Mailman Center and the Department of Pediatrics, University of Miami School of Medicine.

JAMA. 1984;251(24):3267-3269. doi:10.1001/jama.1984.03340480049027

Two infants with prominent frontal bossing, hydrocephalus, microphthalmia, and small, malformed, low-set, undifferentiated ears were born to mothers who had taken isotretinoin in the first trimester of pregnancy. A Dandy-Walker malformation, microcephaly, hypertelorism, small ear canals, cleft palate, small mouth, and congenital heart disease were also observed. Isotretinoin is a potent teratogen in man; maternal ingestion early in pregnancy leads to a distinct clinical pattern of anomalies.

(JAMA 1984;251:3267-3269)