[Skip to Content]
[Skip to Content Landing]
June 22, 1984

Migration and Granulomatous Reaction After Periurethral Injection of Polytef (Teflon)

Author Affiliations

From the Departments of Urology (Drs Malizia, Myers, and Benson, and Mr Utz) and Cell Biology (Mr Sande and Dr Barham) and the Sections of Surgical Pathology (Dr Reiman) and Diagnostic Nuclear Medicine (Dr Dewanjee), Mayo Clinic and Mayo Foundation, Rochester, Minn.

JAMA. 1984;251(24):3277-3281. doi:10.1001/jama.1984.03340480059030

Although patients with urinary incontinence have been treated successfully by periurethral injection of polytef paste, this study in continent animals demonstrates migration of polytef particles from the injection site. We injected polytef paste periurethrally into female dogs and male monkeys. Particles were found at 50 to 70 days in pelvic nodes in six of seven animals and lungs in four of seven (the kidneys and brain were not studied); and at 10 1/2 months in pelvic nodes, lungs, and brain in seven of seven; kidneys in four of seven; and spleen in two of seven. X-ray microanalysis confirmed that the particles were polytef. At 10% months, polytef granulomas were found at all injection sites and some sites of distant migration. Since these granulomas signify chronic foreign-body reaction, we believe that until the long-term effects in humans are known, polytef paste should not be used in children or young adults with normal life expectancy.

(JAMA 1984;251:3277-3281)