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July 13, 1984

Renal Endocrinology

Author Affiliations

Yale University School of Medicine New Haven, Conn

JAMA. 1984;252(2):281. doi:10.1001/jama.1984.03350020069032

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


The title of this text, Renal Endocrinology, serves to highlight the activities of the kidney as the site of hormone and autocoid (acting locally within kidney) production and catabolism, and as a target site for the action of nonrenal hormones.

The first portion reviews the mechanisms of renal production and cellular action of prostaglandins, the kallikrein-kinin system, vitamin D, erythropoietin, and renin-angiotensin. The second section discusses the renal effects of major nonrenal hormones, such as aldosterone, thyroid hormone, and parathyroid hormone, and also the less well-defined action of histamine and serotonin that may subserve an important role in modulating renal hemodynamics and inflammatory response in injury reactions. Lastly, a section is provided on the process by which polypeptide hormones are extracted from plasma and catabolized.

This is the first attempt, to my knowledge, that has characterized renal endocrine functions in a broad fashion. Overall, the text is well organized, lucid,