[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.175.121.230. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
September 7, 1984

Search for male contraceptive complicated by adverse effects

JAMA. 1984;252(9):1101-1102. doi:10.1001/jama.1984.03350090001001

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

Although the famous "Pill" became generally available to women more than 20 years ago, no one so far has found a completely safe and effective male contraceptive agent. Whether based on steroid compounds that interfere with testosterone or on cytotoxic chemicals that interfere directly with spermatogonia, spermatocytes, or spermatids, the most effective methods under investigation also produce unacceptable side effects, often including impotence and loss of libido.

A thoroughly satisfactory, clinically tested solution still lies far down the road. But according to several researchers at the recent Seventh International Congress of Endocrinology in Quebec City, Canada, it may be possible to alleviate serious side effects of some of the most promising male contraceptive agents.

LHRH Antagonists  Many proposed methods suppress production of spermatozoa through action of synthetic hormones. For example, long-term administration of analogues to luteinizing hormone-releasing hormone (LHRH, sometimes called GnRH or gonadotropin-releasing hormone), which normally stimulates secretion of

×