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September 7, 1984

Medicine at a Glance

JAMA. 1984;252(9):1102-1103. doi:10.1001/jama.1984.03350090002002

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Marfan's Syndrome Surgery:  Prophylactic surgery involving replacement of the dilated aortic root and aortic valve may increase the life expectancy of patients with Marfan's syndrome, according to Reed E. Pyeritz, MD, PhD, director of the Medical Genetics Clinic and associate professor of medicine and of pediatrics, the Johns Hopkins University School of Medicine, Baltimore. Pyeritz presented the preliminary results of this surgery, which has been performed on 45 patients at Hopkins so far, at the Short Course in Medical and Experimental Mammalian Genetics held this summer at the Jackson Laboratory in Bar Harbor, Me, and sponsored by the March of Dimes Birth Defects Foundation. He says he is waiting until 50 patients have undergone the procedure to analyze and report the full actuarial results. (His group at Hopkins has 300 to 400 patients with the disease.)Cardiovascular complications—mitral valve disease in infants and aortic root dissection or chronic aortic regurgitation