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In view of the many clinical nephrology texts that have appeared in the past few years, one can legitimately ask whether this long (797 pages) monograph by Brenner and Lazarus is really needed. After a careful review, I am convinced that the end product more than justifies its existence.
The authors' aim is to provide a state-of-the-art, in-depth volume dealing with all aspects of acute renal failure. The book is divided into five sections: pathophysiology, clinical spectrum, metabolic consequences, management, and protective mechanisms and mechanisms for enhancing recovery.
Section 1 reviews the old and new studies on the pathogenesis of acute renal failure. The first two chapters deal with cellular and biochemical studies and suggest that important new research directions have been found. While coverage of the various theories and experimental models of acute renal failure is generally well done and balanced, I found the chapter on experimental obstruction of
Cronin RE. Acute Renal Failure. JAMA. 1984;252(11):1476–1477. doi:10.1001/jama.1984.03350110070043
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