[Skip to Content]
[Skip to Content Landing]
Article
October 5, 1984

Renal Failure Secondary to Massive Infusion of Vitamin C

Author Affiliations

Clearwater, Fla

JAMA. 1984;252(13):1684. doi:10.1001/jama.1984.03350130016019

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor.—  We feel compelled to report the complications of high-dose vitamin C infusion in patients with renal insufficiency. Vitamin C, one of whose main metabolites is oxalate, can produce permanent renal failure in patients with preexisting renal insufficiency.

Report of a Case.—  A 70-year-old man with documented renal insufficiency came to a "chelation therapy" center for treatment of claudication. Previous testing (one day before) showed the serum creatinine level to be 5.0 mg/dL. An estimated creatinine clearance was 19 mL/min. The serum hematocrit value was 29.4%. To be prepared for chelation—the intravenous (IV) administration of edetic acid—the patient was given 2.5 g of vitamin C in 500 mL of solution of 5% dextrose in water for five hours. The patient tolerated the infusion well; however, 12 hours later he experienced severe lancinating bilateral flank pain, passed 3 mL of hematuria, and became anuric.The patient was transferred to

×