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Replacement therapy, either with transplants or artificial prosthetic devices, offers a gift of life to those with end-stage debilitating diseases. For the many with primary liver cancer, congenital metabolic deficiency, or acquired parenchymatous liver disease, a liver transplant is the only hope. With the advent of cyclosporine immunosuppression, Roy Y. Calne reports that there is now "obviously a worldwide need for liver grafting," which has been developed and performed in only four centers until recently. For those interested in the development of new programs, Professor Calne has edited, in classic British style, Liver Transplantation, the first and currently only such extensive work to my knowledge devoted to liver grafting.
The material presented is a compilation of the broad experiences and research from four pioneering centers—Addenbrooke's Hospital, Cambridge, England, with the Liver Unit, Kings College Hospital, London; Groningen in Sweden; Hannover in West Germany; and our own unit under Tom Starzl,
McCabe R. Liver Transplantation: The Cambridge— King's College Hospital Experience. JAMA. 1984;252(21):3028–3029. doi:10.1001/jama.1984.03350210070046
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