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December 14, 1984

Interhepatic Oily Contrast Material

Author Affiliations

Kyushu University Hospital Fukuoka, Japan

JAMA. 1984;252(22):3130. doi:10.1001/jama.1984.03350220038020

To the Editor.—  We read with great interest the article, "New Contrast Material Improves Detection of Liver and Spleen Metastases." Dr Michael Vermess and colleagues deserve congratulations for their meaningful work. The etiodized oil emulsion 13 they developed selectively opacifies the normal liver and spleen—but not tumors in these organs—for computed tomographic (CT) examination.Conversely, we administer an oily contrast material—iodized oil (Lipiodol)—via the hepatic artery, using the Seldinger technique.2 This approach has proved to be most useful for the diagnosis and treatment of primary and secondary liver tumors. Given through the hepatic artery, this oily contrast medium remains only in the neoplastic tissue for an extended time. There is no evidence of deposits in liver parenchyma on the plain x-ray film, and CT and ultrasound examinations clearly demonstrate the tumor itself and its extension. This feature is prominent particularly in cases of vascular-rich tumors, such as are seen