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December 21, 1984

Hypersensitivity Associated With Ranitidine

Author Affiliations

St Agnes Medical Center Philadelphia

JAMA. 1984;252(23):3252. doi:10.1001/jama.1984.03350230014016

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To the Editor.—  The following case of hypersensitivity associated with ranitidine (Zantac) seems worthy of report. I am unaware of similar cases in the literature, and, except for rash, hypersensitivity is not mentioned in the Zantac prescribing information.

Report of a Case.—  A 40-year-old woman being treated for gastritis failed to respond to a regimen of antacids and diazepam. Ranitidine, 150 mg twice a day, was prescribed in place of the antacids. The first dose, taken at bedtime, was accompanied by light-headedness. Two hours after the second dose of ranitidine, taken the next morning, she experienced shortness of breath, wheezing, a generalized pruritic maculopapular eruption, and rhinorrhea.When seen at the emergency room of St Agnes Medical Center, Philadelphia, she had expiratory wheezes on auscultation and a generalized maculopapular eruption. There was marked injection of the conjunctivae. Her symptoms responded to parenteral and oral diphenhydramine.

Comment.—  The nature of the